We have successfully achieved formal total synthesis of Tamiflu FTY720 derivatives, ent-calystegine B4 and indolizidine 167B. For the preparation of FTY720 derivatives, we developed a new Heck-Matsuda reaction methodology of allylic nitro compounds and achieved very short-step synthesis. Recently we have also achieved a new methodology of double allylation reaction of allylic nitro compounds that are potentially useful for organic synthesis.
Publications
Nakano, T.; Miyazaki, K.; Kamimura, A. J. Org. Chem. 2014, 79, 8103 – 8109: DOI: 10.1021/jo5013042
Kamimura, A.; Miyazaki, K.; Suzuki, S.; Ishikawa, S.; Uno, H. Org. Biomol. Chem. 2012, 10, 4362 – 4366.
Kamimura, A.; Nakano, T. J. Org. Chem. 2010, 75, 3133-3136
Nakano, T.; Miyahara, M.; Itoh, T.; Kamimura, A, Eur. J. Org. Chem. 2012, 2161 – 2166
Kamimura, A.; Nagata, Y.; Kadowaki, A.; Uno, H. Tetrahedron 2007, 63, 11856-11861
